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Patterns were similar for attained systolic blood pressure.ConclusionsAntihypertensive treatment reduces the risk of mortality and cardiovascular morbidity in people with diabetes mellitus and a systolic blood pressure more than 140 mm Hg. If systolic blood pressure is less than 140 mm Hg, however, further treatment is associated with an increased risk of cardiovascular death, with no observed benefit.IntroductionBlood pressure goals in people with diabetes mellitus have been extensively debated during the past decade.1 2 3 For many years, guidelines have recommended treating patients to achieve a blood pressure of less than 130/80 mm Hg.4 5 6 Systematic reviews have questioned the evidence for these recommendations.7 8 During 2013 multiple hypertension guidelines were updated.9 10 11 Generally, the treatment goals for people with diabetes were changed to less than 140/90 mm Hg, but some guidelines still opt for lower targets in certain patient groups.9 12 Last year pandora earrings, a new systematic review was published,13 concluding that treating people with a systolic blood pressure (SBP) already less than 140 mm Hg is associated with a reduced risk of stroke and albuminuria, and therefore challenged the relaxation of guidelines. All previous systematic reviews only analysed previously published data.7 8 13We assessed the effect of blood pressure lowering treatment in people with diabetes mellitus, including previously unpublished data.

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